What Does Joint Pain From Statins Feel Like?

Posted on | By Jason S. Harris

What Does Joint Pain From Statins Feel Like?

You may feel this pain as a soreness, tiredness or weakness in your muscles. The pain can be a mild discomfort, or it can be severe enough to make your daily activities difficult. However, researchers have found a “nocebo” effect when it comes to perceived muscle pain and statins.

Does statin joint pain go away?

In most cases, if you’re going to have muscle pain from statins, you will notice it soon after you start taking the medication. For many people, however, this side effect is temporary and goes away somewhat quickly.

Which statin is safest for liver?

Based on records from the Swedish national registry, their results demonstrate that individuals who took a lipophilic statin (in this case atorvastatin or simvastatin) were at a significantly lower risk of developing liver cancer than those who were not taking a statin (3.3% versus 8.1%).

Which statin has the highest risk of liver failure?

Atorvastatin causes elevations in transaminases greater than 3-fold the ULN in approximately 0.5% of all cases, with an absolute risk of 1.2% with high-intensity therapy. Atorvastatin is the most common cause of clinically significant liver injury among statins with a reported incidence of 1/17 000 users.

Is statin liver damage reversible?

People that experience statin induced liver injury have a generally positive prognosis. These injuries are usually short-term and reversible.

Which statin is least likely to cause liver?

Simvastatin, lovastatin, fluvastatin, and atorvastatin are metabolized by cytochrome P-450, while pravastatin, rosuvastatin, and pitavastatin remain almost unaffected by any hepatic metabolic processes.

Do statins affect thinking?

Statins have been linked to short-term reversible cognitive impairment since early safety and tolerability testing [13]. During a phase I clinical trial of atorvastatin, escalating doses showed a dose-dependent adverse reaction of mild, transient, restlessness, euphoria, and mental confusion [13].
Feb 27, 2018

Is memory loss from statins reversible?

Keep in mind that even if evidence shows that statins do cause memory problems, it may not be a common problem—and it may even be reversible. It’s likely that if a person stopped taking the medication, the effect would get better.
Jul 4, 2022

Do statins cause brain fog?

While statins have a lot of health benefits and are safe for most people to use, there are some side effects. These can include: Muscle aches and pain. Memory loss or brain fog.
Jun 21, 2021

Can statins cause early dementia?

Researchers looked at data on statin use among 18,446 people, ages 65 or older, who had taken part in a large randomized trial of aspirin. The researchers found that over a follow-up period of almost five years, people who took statins weren’t any more likely than non-users to have dementia.

Do statins lower testosterone in men?

Statins lowered testosterone by about 3.4% among men (-0.66 nmol/l, 95% confidence interval (CI) -0.14 to -1.18) in both fixed and random effects models, and the estimate was similar (-0.73 nmol/l, 95% CI -0.20 to -1.26) including only the higher quality trials [15,16,29].

Do statin drugs cause erectile dysfunction?

Despite what you might have heard, statins (cholesterol-lowering drugs) like atorvastatin, simvastatin, and rosuvastatin do not cause ED. Men with ED who take statins for high cholesterol actually see a 25% improvement in self-reported erectile function.

What percentage of people have side effects from rosuvastatin?

In the rosuvastatin calcium controlled clinical trials database (placebo or active-controlled) of 5394 patients with a mean treatment duration of 15 weeks, 1.4% of patients discontinued due to adverse reactions. The most common adverse reactions that led to treatment discontinuation were: myalgia. abdominal pain.

Does rosuvastatin have more side effects than other statins?

BOSTON, May 23-A new analysis of post-marketing safety reports suggests that patients using Crestor (rosuvastatin), a super-potent statin, are more likely to develop serious side effects than patients taking Lipitor (atorvastatin), Zocor (simvastatin), or Pravachol (pravastatin).

Is rosuvastatin a good statin?

Statins all work in the same way, but they differ in how well they lower cholesterol. When used at a higher dose, rosuvastatin and atorvastatin produce a bigger reduction in cholesterol than the other statins. If you have a side effect with one statin, it may not happen with another.

How can I reduce the side effects of rosuvastatin?

How to relieve statin side effects

1

Take a brief break from statin therapy. …

2

Switch to another statin drug. …

3

Change your dose. …

4

Take it easy when exercising. …

5

Consider other cholesterol-lowering medications. …

6

Try coenzyme Q10 supplements.


Which statin has least muscle side effects?

Even though all statins are similar chemically, they have some minor differences that could impact how likely they are to cause muscle pain. Simvastatin is the most likely to cause muscle pain, and fluvastatin is the least likely.
Mar 31, 2565 BE

Which statin is most easily tolerated?

In the trials that directly compared individual statins head-to-head, simvastatin was significantly more tolerable than atorvastatin (OR, 0.61; 95% CI, 0.42–0.89; I2, 71.9%) and rosuvastatin (OR, 0.49; 95% CI, 0.27–0.88; I2, 0.0%).
Jul 1, 2556 BE

What cholesterol medication has the least side effects?

In general, statins are effective, have very few side effects, and are well-tolerated, meaning that if side effects do occur, they usually aren’t bad enough for people to stop taking them. It’s widely accepted that the benefits of statins greatly outweigh the risk of side effects.

What is the safest statin for elderly?

Atorvastatin or fluvastatin are usually recommended because there is no need to adjust the dose according to the glomerular filtration rate [28]. In patients without diagnosed atherosclerotic cardiovascular disease, it is indicated a moderate dose of statin, such as atorvastatin 20 mg daily [28].

Which statin is most easily tolerated?

In the trials that directly compared individual statins head-to-head, simvastatin was significantly more tolerable than atorvastatin (OR, 0.61; 95% CI, 0.42–0.89; I2, 71.9%) and rosuvastatin (OR, 0.49; 95% CI, 0.27–0.88; I2, 0.0%).

Is there a new statin without side effects?

Another newer option is actually a statin. It’s called pitavastatin, or Livalo. It has the same LDL- and total cholesterol-lowering property as all the other statins, but somehow doesn’t give the muscle aches. A lot of people have had a lot of success taking this over any of the other statins out there.

Is Purpura a side effect of statins?

A clinical trial on drug-induced thrombocytopenia in 309 patients did not identify statins as the culprit,6 but there certainly have been case reports related to simvastatin and atorvastatin-induced thrombocytopenic purpura.
May 19, 2010

Do statins affect your skin?

Statins have also been associated with a number of cutaneous conditions (e.g. eczematous skin rash, cutaneous lupus erythematosus, porphyria cutanea tarda, bullous dermatosis, UV-B phototoxicity, acute generalized exanthematous pustulosis, cheilitis, photosensitivity and dermatomyositis-like syndrome).

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Men with ED who take statins for high cholesterol actually see a 25% improvement in self-reported erectile function.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Does statin joint pain go away?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “In most cases, if you’re going to have muscle pain from statins, you will notice it soon after you start taking the medication. For many people, however, this side effect is temporary and goes away somewhat quickly.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Do statins affect thinking?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Statins have been linked to short-term reversible cognitive impairment since early safety and tolerability testing [13]. During a phase I clinical trial of atorvastatin, escalating doses showed a dose-dependent adverse reaction of mild, transient, restlessness, euphoria, and mental confusion [13].Feb 27, 2018″[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Is rosuvastatin a good statin?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Statins all work in the same way, but they differ in how well they lower cholesterol. When used at a higher dose, rosuvastatin and atorvastatin produce a bigger reduction in cholesterol than the other statins. If you have a side effect with one statin, it may not happen with another.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Do statins lower testosterone in men?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Statins lowered testosterone by about 3.4% among men (-0.66 nmol/l, 95% confidence interval (CI) -0.14 to -1.18) in both fixed and random effects models, and the estimate was similar (-0.73 nmol/l, 95% CI -0.20 to -1.26) including only the higher quality trials [15,16,29].”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “What cholesterol medication has the least side effects?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “In general, statins are effective, have very few side effects, and are well-tolerated, meaning that if side effects do occur, they usually aren’t bad enough for people to stop taking them. It’s widely accepted that the benefits of statins greatly outweigh the risk of side effects.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Is there a new statin without side effects?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Another newer option is actually a statin. It’s called pitavastatin, or Livalo. It has the same LDL- and total cholesterol-lowering property as all the other statins, but somehow doesn’t give the muscle aches. A lot of people have had a lot of success taking this over any of the other statins out there.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Is statin liver damage reversible?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “People that experience statin induced liver injury have a generally positive prognosis. These injuries are usually short-term and reversible.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Does rosuvastatin have more side effects than other statins?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “BOSTON, May 23-A new analysis of post-marketing safety reports suggests that patients using Crestor (rosuvastatin), a super-potent statin, are more likely to develop serious side effects than patients taking Lipitor (atorvastatin), Zocor (simvastatin), or Pravachol (pravastatin).”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Which statin is least likely to cause liver?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Simvastatin, lovastatin, fluvastatin, and atorvastatin are metabolized by cytochrome P-450, while pravastatin, rosuvastatin, and pitavastatin remain almost unaffected by any hepatic metabolic processes.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Is Purpura a side effect of statins?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “A clinical trial on drug-induced thrombocytopenia in 309 patients did not identify statins as the culprit,6 but there certainly have been case reports related to simvastatin and atorvastatin-induced thrombocytopenic purpura.May 19, 2010″[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Which statin is most easily tolerated?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “In the trials that directly compared individual statins head-to-head, simvastatin was significantly more tolerable than atorvastatin (OR, 0.61; 95% CI, 0.42–0.89; I2, 71.9%) and rosuvastatin (OR, 0.49; 95% CI, 0.27–0.88; I2, 0.0%).Jul 1, 2556 BE”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “What is the safest statin for elderly?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Atorvastatin or fluvastatin are usually recommended because there is no need to adjust the dose according to the glomerular filtration rate [28]. In patients without diagnosed atherosclerotic cardiovascular disease, it is indicated a moderate dose of statin, such as atorvastatin 20 mg daily [28].”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “How can I reduce the side effects of rosuvastatin?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “How to relieve statin side effects1Take a brief break from statin therapy. … 2Switch to another statin drug. … 3Change your dose. … 4Take it easy when exercising. … 5Consider other cholesterol-lowering medications. … 6Try coenzyme Q10 supplements.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “What percentage of people have side effects from rosuvastatin?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “In the rosuvastatin calcium controlled clinical trials database (placebo or active-controlled) of 5394 patients with a mean treatment duration of 15 weeks, 1.4% of patients discontinued due to adverse reactions. The most common adverse reactions that led to treatment discontinuation were: myalgia. abdominal pain.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Do statins affect your skin?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Statins have also been associated with a number of cutaneous conditions (e.g. eczematous skin rash, cutaneous lupus erythematosus, porphyria cutanea tarda, bullous dermatosis, UV-B phototoxicity, acute generalized exanthematous pustulosis, cheilitis, photosensitivity and dermatomyositis-like syndrome).”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Can statins cause early dementia?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Researchers looked at data on statin use among 18,446 people, ages 65 or older, who had taken part in a large randomized trial of aspirin. The researchers found that over a follow-up period of almost five years, people who took statins weren’t any more likely than non-users to have dementia.”[[CB-C]][[CB-C]]][[CB-C]]

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