What Are The Risks Of Taking Zofran While Pregnant?

Posted on | By Jason S. Harris

What Are The Risks Of Taking Zofran While Pregnant?

Original work suggested no increase in birth defects in women who took ondansetron early in pregnancy. However, more recent studies have raised concern over the possibility of a doubling in risk of cleft palate and heart defects in newborns exposed to ondansetron during pregnancy.

Why can’t you take Zofran first trimester?

One recent meta-analysis of eight studies suggested that exposure to ondansetron in the first trimester could cause a very small increase in the risk of heart defects and orofacial malformations like cleft palate in babies.

Is Zofran OK in first trimester?

Zofran is approved by the Food and Drug Administration (FDA) for use to fight off nausea related to chemotherapy. It is not currently approved by the FDA for morning sickness. Even so, most studies show that ondansetron is safe to use during the first trimester when most women experience morning sickness.
Dhuʻl-Q. 4, 1442 AH

Will Zofran hurt my unborn baby?

If you are pregnant and have taken ondansetron or Zofran® during pregnancy, I want to reassure you that it likely has not affected your baby. Even if the increased risk for cleft palate or heart defects turns out to be true, the risk to your baby is still very, very small.
Jul 14, 2015

Does Zofran cause birth defects in first trimester?

The most recent study, published in the December 2014 issue of The American Journal of Obstetrics and Gynecology found that taking Zofran, especially during the first trimester, increases the risk of severe birth defects.
Jan 26, 2022

What are the risks of taking Zofran while pregnant?

Original work suggested no increase in birth defects in women who took ondansetron early in pregnancy. However, more recent studies have raised concern over the possibility of a doubling in risk of cleft palate and heart defects in newborns exposed to ondansetron during pregnancy.

Is Zofran OK in first trimester?

Zofran is approved by the Food and Drug Administration (FDA) for use to fight off nausea related to chemotherapy. It is not currently approved by the FDA for morning sickness. Even so, most studies show that ondansetron is safe to use during the first trimester when most women experience morning sickness.

Why can’t you take Zofran first trimester?

One recent meta-analysis of eight studies suggested that exposure to ondansetron in the first trimester could cause a very small increase in the risk of heart defects and orofacial malformations like cleft palate in babies.

Is Zofran OK in first trimester?

Zofran is approved by the Food and Drug Administration (FDA) for use to fight off nausea related to chemotherapy. It is not currently approved by the FDA for morning sickness. Even so, most studies show that ondansetron is safe to use during the first trimester when most women experience morning sickness.

Why is Zofran contraindicated in pregnancy?

Original work suggested no increase in birth defects in women who took ondansetron early in pregnancy. However, more recent studies have raised concern over the possibility of a doubling in risk of cleft palate and heart defects in newborns exposed to ondansetron during pregnancy.

What is a potential downside to ondansetron use in pregnancy?

Risk of congenital anomalies – Available data suggest that use of ondansetron in early pregnancy is not associated with a high risk of congenital malformations, but a small absolute increase in risk of cardiovascular malformations (especially septum defects) and cleft palate may exist [87-90].
Aug 30, 2022

Is Zofran FDA approved for pregnancy?

Although not specifically approved by the FDA for the management of nausea and vomiting during pregnancy, ondansetron is now commonly used during pregnancy.

Is Zofran OK to take while pregnant?

Zofran is approved by the Food and Drug Administration (FDA) for use to fight off nausea related to chemotherapy. It is not currently approved by the FDA for morning sickness. Even so, most studies show that ondansetron is safe to use during the first trimester when most women experience morning sickness.
Jun 14, 2021

Does Zofran cause birth defects?

The most recent study, published in the December 2014 issue of The American Journal of Obstetrics and Gynecology found that taking Zofran, especially during the first trimester, increases the risk of severe birth defects.

Is ondansetron safe in early pregnancy?

Ondansetron. Although ondansetron has limited safety data in pregnancy, it is often prescribed for women with hyperemesis gravidarum. It is not recommended as first-line therapy, especially in the first trimester of pregnancy. Ondansetron commonly causes constipation, which may already be a problem in pregnancy.

Can you take Zofran at 8 weeks pregnant?

A new study published in the New England Journal of Medicine concluded that the popular drug Zofran (used to treat nausea, vomiting and in some cases, hyperemesis gravidarum, in early pregnancy) poses no risk to the developing fetus.

Is ondansetron Zofran safe during pregnancy?

Although not specifically approved by the FDA for the management of nausea and vomiting during pregnancy, ondansetron is now commonly used during pregnancy.
Jul 23, 2020

Will Zofran hurt my unborn baby?

Most studies have not reported an increased chance for birth defects among thousands of people who used ondansetron in pregnancy. A few studies reported a very small (less than 1%) increase in the chance for a cleft palate (an opening in the roof of the mouth that can be repaired with surgery) or a heart defect.
Sep 1, 2022

Why can’t you take Zofran first trimester?

One recent meta-analysis of eight studies suggested that exposure to ondansetron in the first trimester could cause a very small increase in the risk of heart defects and orofacial malformations like cleft palate in babies.
Sep 30, 2020

How safe is it to take Zofran while pregnant?

Taking Zofran while pregnant is low risk, and it has been prescribed for years for pregnancy nausea.
Sep 30, 2020

What can Zofran cause during pregnancy?

Risk of congenital anomalies – Available data suggest that use of ondansetron in early pregnancy is not associated with a high risk of congenital malformations, but a small absolute increase in risk of cardiovascular malformations (especially septum defects) and cleft palate may exist [87-90].
Aug 30, 2022

Does Zofran cause birth defects in first trimester?

The most recent study, published in the December 2014 issue of The American Journal of Obstetrics and Gynecology found that taking Zofran, especially during the first trimester, increases the risk of severe birth defects.

What drugs should not be taken with atorvastatin?

Certain drugs can interact with atorvastatin (Lipitor) and increase its side effects. These include fibrates, niacin supplements, cyclosporine, clarithromycin, itraconazole, HIV protease inhibitors, oral contraceptives containing norethindrone or ethinyl estradiol, digoxin, rifampin, and colchicine.
Feb 5, 2022

What meds interfere with Zofran?

Drug Interactions

Apomorphine.

Phenytoin, carbamazepine and rifampin.

Tramadol.

Selective serotonin reuptake inhibitors (SSRI) and serotonin and norepinephrine reuptake inhibitors (SNRI)

Temazepam.

Drugs affecting the cytochrome P-450 drug-metabolizing enzyme.


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Even if the increased risk for cleft palate or heart defects turns out to be true, the risk to your baby is still very, very small.Jul 14, 2015″[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Does Zofran cause birth defects?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “The most recent study, published in the December 2014 issue of The American Journal of Obstetrics and Gynecology found that taking Zofran, especially during the first trimester, increases the risk of severe birth defects.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Why can’t you take Zofran first trimester?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “One recent meta-analysis of eight studies suggested that exposure to ondansetron in the first trimester could cause a very small increase in the risk of heart defects and orofacial malformations like cleft palate in babies.”[[CB-C]][[CB-C]], [[CB-O]]”@type”: “Question”,”name”: “Is Zofran OK in first trimester?”,”acceptedAnswer”: [[CB-O]]”@type”: “Answer”,”text”: “Zofran is approved by the Food and Drug Administration (FDA) for use to fight off nausea related to chemotherapy. It is not currently approved by the FDA for morning sickness. Even so, most studies show that ondansetron is safe to use during the first trimester when most women experience morning sickness.Dhuʻl-Q. 4, 1442 AH”[[CB-C]][[CB-C]]][[CB-C]]

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